Effect of Methysticin on osteoblast function under oxidative stress through Nrf2/HO-1 signaling pathway: in vitro study

Introduction Bone healing is reported to be disturbed by excessive oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is responsible for regulating antioxidant systems, and it also has an important role in fracture healing. Our previous study showed that Nrf2-knockout mice had reduced fracture callus compared with wild type mice, but the effect of pharmacological Nrf2 induction on bone healing is still unknown. Given that...