Cell biology

Biology

Surgery

Endocrinology

Cartilage

Bone remodeling

Femur

Homeostasis

Anatomy

Internal medicine

Medicine

Pathology

Osteologie/Osteology

Introduction Nuclear factor erythroid 2–related factor 2 (Nrf2) is crucial for maintaining cellular redox homeostasis and it also affects bone and cartilage metabolism. However, its age- and gender- dependent influence has yet to be described. The aim of this study was to investigate the role of Nrf2 on bone and cartilage acquisition in young and elderly mice by using a micro-computed tomography (µCT).

Chronic Nrf2 deficiency affects age- and gender- dependent bone and cartilage acquisition in murine femur