Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

Volume: 39, Issue: 4
Published: Apr 12, 2021
Abstract
Small cell neuroendocrine cancers (SCNCs) are recalcitrant cancers arising from diverse primary sites that lack effective treatments. Using chemical genetic screens, we identified inhibition of ataxia telangiectasia and rad3 related (ATR), the primary activator of the replication stress response, and topoisomerase I (TOP1), nuclear enzyme that suppresses genomic instability, as synergistically cytotoxic in small cell lung cancer (SCLC). In a...
Paper Details
Title
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
Published Date
Apr 12, 2021
Volume
39
Issue
4
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