Selectivity

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Bifunctional

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Organic synthesis

Organocatalysis

Nature Reviews Chemistry

Developments in synthetic chemistry are increasingly driven by improvements in the selectivity and sustainability of transformations. Bifunctional reagents, either as dual coupling partners or as a coupling partner in combination with an activating species, offer an atom-economic approach to chemical complexity, while suppressing the formation of waste. These reagents are employed in organic synthesis thanks to their ability to form complex organic architectures and empower novel reaction pathways. This Review describes several key bifunctional reagents by showcasing selected cornerstone research areas and examples, including radical reactions, C–H functionalization, cross-coupling, organocatalysis and cyclization reactions.                                                                  Developments in synthetic chemistry are increasingly driven by attempts to improve both selectivity and sustainability. This Review highlights the versatility of bifunctional reagents in generating chemical complexity with enhanced atom-economy-leveraging radical reactions, C–H functionalizations, cross-couplings, organocatalysed processes and cyclizations.

Bifunctional reagents in organic synthesis