Enzyme

Monoclonal antibody

Complement system

Classical complement pathway

Antibody

Chemistry

Protease

Immunology

Autoimmune hemolytic anemia

Serine protease

Cold agglutinin disease

Cold Agglutinin

Hemolysis

Biochemistry

Medicine

New England Journal of Medicine

Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized monoclonal antibody, selectively targets the C1s protein, a C1 complex serine protease responsible for activating this pathway.

Sutimlimab in Cold Agglutinin Disease