Supercritical carbon dioxide

Captopril

Chromatography

Solubility

Endocrinology

Gliclazide

Insulin

Supercritical fluid

Radiology

Thermodynamics

Physics

Organic chemistry

Blood pressure

Internal medicine

Analytical Chemistry (journal)

Medicine

Chemistry

The Journal of Supercritical Fluids

The solubility of drugs in supercritical carbon dioxide (ScCO2) is crucial information for crystal engineering designs and pharmaceutical applications. A semi-flow apparatus was used to measure the solubility of gliclazide and captopril in ScCO2 at 308.2 K, 318.2 K, and 328.2 K within the pressure range of 10.0–18.6 MPa. The newly measured solubility data were correlated and confirmed to be self-consistency with four semi-empirical correlation models: Chrastil, Méndez-Santiago & Teja (MST), Bartle, and Kumar & Johnston (K-J). The newly measured data were then used to evaluate the accuracy of three approaches based on the Peng-Robinson equation of state (PR EOS). PR EOS combining with the Wilson model through the Wong-Sandler mixing rule with two adjustable parameters shown excellent fit with experimental data, while PR EOS combining with the COSMO-SAC model through the MHV1 mixing rule provided reasonable solubility prediction without adjustable parameters.

Measurement and modeling of solubility of gliclazide (hypoglycemic drug) and captopril (antihypertension drug) in supercritical carbon dioxide