Active ingredient

Quantum mechanics

Diffusion layer

Engineering

Biology

Materials science

Layer (electronics)

Particle size

Computer science

Chemical engineering

Classical mechanics

Geology

Dissolution

Oceanography

Physical chemistry

Thermodynamics

Boundary layer

Physics

Nanotechnology

Bioinformatics

Diffusion

Work (physics)

Pharmacology

Artificial intelligence

Particle (ecology)

Kinetics

Medicine

Chemistry

Mechanics

Class (philosophy)

ACS Omega

In this work, a diffusion-theory-based model has been devised to simulate dissolution kinetics of a poorly water-soluble drug, ibuprofen. The model was developed from the Noyes–Whitney equation in which the dissolution rate term is a function of the remaining particulate surface area and the concentration gradient across the boundary layer. Other dissolution parameters include initial particle size, diffusion coefficient, material density, and diffusion boundary layer thickness. It is useful for predicting nonsink circumstances under which pure API polydisperse powders are suspended in a well-mixing tank. The model was used to compare the accuracy of simulations using spherical (single dimensional characteristic length) and cylindrical particle (multidimensional characteristic lengths) geometries, with and without size-dependent diffusion layer thickness. Experimental data was fitted to the model to obtain the diffusion layer thickness as well as used for model validation and prediction. The CSDs of postdissolution were also predicted with this model, demonstrating good agreement between theory and experiment.

Dissolution Kinetics of a BCS Class II Active Pharmaceutical Ingredient: Diffusion-Based Model Validation and Prediction