Application of RP-18 TLC retention data to prediction of transdermal absorption of drugs

The dermal permeability coefficient (log Kp) of 14 drugs (temazepam, alprazolam, bromazepam, elenium, oxazepam, lorazepam, lormetazepam, clotrazepate, ranitidine, methyldopa, piroxicam, amizepine, paracetamol, aspirin) was estimated in silico using DERMWIN v. 2.0 software. RP-18 thin layer chromatographic retention data were collected using methanol-water mobile phases containing between 50 and 90% (v/v) of methanol. The retention factor (Rf)...