Pathology

Conjunctiva

Sclera

Disease

Scleritis

Surgery

Dermatology

Immunology

Episcleritis

Rheumatoid arthritis

Vasculitis

Uveitis

Systemic vasculitis

Medicine

Clinical and Experimental Dermatology

that his scleritis was attributable to a noninfectious pathogenesis.Unlike the conjunctiva, which consists of nonkeratinizing stratified columnar epithelium and expresses Dsg3, sclera is not an epithelium.Because the sclera is essentially acellular, containing only a few fibroblasts and nonbranching traversing vessels, it is not affected by anti-Dsg antibody.Scleritis is a type of refractory autoimmune or infectious inflammation, which is accompanied by conjunctival and surface or deeper scleral vascular congestion. 3Scleritis is often accompanied by systemic inflammatory diseases, such as rheumatoid arthritis, connective tissue disease and vasculitis.Although pathogenic mechanisms of scleritis associated with systemic diseases have been poorly understood, autoimmunity and scleral destruction by resident cells and infiltrating leucocytes or matrix metalloproteinases have been proposed. 4,5ortunately, our patient's scleritis improved promptly without any sequelae, but, unlike conjunctivitis, exacerbation of scleritis can lead to visual disturbance.Consequently, dermatologists should be alert to scleritis in patients with PV with severe eye complications.

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