TLR3

Immune system

Cancer cell

Cancer research

TANK-binding kinase 1

Carcinogenesis

Biology

Toll-like receptor

Mitogen-activated protein kinase kinase

Cell biology

Cancer

Signal transduction

IRF3

Innate immune system

Protein kinase C

Immunology

Genetics

Cancer Cell

Ghosh et al. show that mutant p53 suppresses downstream signaling from the cGAS/STING cytosolic DNA-sensing pathway by interacting with TANK-binding protein kinase 1 (TBK1), resulting in the attenuation of the type I interferon response and the promotion of tumor growth through immune evasion.

Mutant p53 suppresses innate immune signaling to promote tumorigenesis