Associations between artificial light at night and risk for thyroid cancer: A large US cohort study.

Published on May 1, 2021in Cancer6.86
· DOI :10.1002/CNCR.33392
Dong Zhang7
Estimated H-index: 7
(University of Arkansas for Medical Sciences),
Rena R. Jones21
Estimated H-index: 21
+ 2 AuthorsQian Xiao25
Estimated H-index: 25
(University of Texas Health Science Center at Houston)
Background Light at night (LAN) inhibits nighttime secretion of melatonin and may cause circadian disruption, which may be a risk factor for cancer. Recent studies have linked high LAN exposure with elevated breast cancer risk. Given that breast cancer may share a common hormone-dependent etiology with thyroid cancer and that circadian rhythms play a role in regulating thyroid function, the authors hypothesized that exposure to LAN is positively associated with thyroid cancer incidence. Methods This study examined the association between LAN and thyroid cancer incidence in the National Institutes of Health-American Association of Retired Persons Diet and Health Study. LAN exposure was estimated from satellite data and was linked to residential addresses at the baseline. Incident thyroid cancer cases were ascertained via linkage to state cancer registries. Cox regression was used to determine the relationship between LAN and thyroid cancer risk, with adjustments made for sociodemographic, lifestyle, and other environmental factors. Results Among 464,371 participants, a positive association was found between LAN and thyroid cancer risk. Specifically, in comparison with the lowest quintile of LAN, the highest quintile was associated with a 55% increase in risk (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.18-2.02). The association was primarily driven by papillary thyroid cancer and was stronger in women (HR, 1.81; 95% CI, 1.26-2.60) than men (HR, 1.29; 95% CI, 0.86-1.94). In women, the association was stronger for localized cancer, whereas in men, the association was stronger for a more advanced stage. Results were consistent across different tumor sizes. Conclusions LAN was positively associated with thyroid cancer risk. Future studies are needed to confirm this association and identify underlying biological mechanisms.
#1Mark Lee (Cornell University)H-Index: 9
#2Ann E Powers (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 4
Last. Jennifer L. Marti (Cornell University)H-Index: 13
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#1Qian Xiao (University of Texas Health Science Center at Houston)H-Index: 25
#2Peter James (Harvard University)H-Index: 35
Last. Rena R. Jones (NIH: National Institutes of Health)H-Index: 21
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Circadian disruption may play a role in breast carcinogenesis. Previous studies reported relationships between outdoor light at night (LAN) and the breast cancer risk, but their findings are mixed. There is also a need to examine LAN and breast cancer incidence according to different individual and environmental characteristics to identify subpopulations at greater risk associated with LAN exposure. We studied residential outdoor LAN estimated from satellite imagery at baseline (1996) in relatio...
#1Allen S. Ho (Cedars-Sinai Medical Center)H-Index: 24
#2Michael Luu (Cedars-Sinai Medical Center)H-Index: 13
Last. Zachary S. Zumsteg (Cedars-Sinai Medical Center)H-Index: 28
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Importance While well-differentiated papillary thyroid carcinoma (WDPTC) outcomes have been well characterized, the prognostic implications of more aggressive variants are far less defined. The rarity of these subtypes has led to their consolidation as intermediate risk for what are in fact likely heterogeneous diseases. Objective To analyze incidence, clinicopathologic characteristics, and outcomes for aggressive variants of papillary thyroid carcinoma (PTC). Design, Setting, and Participants T...
#1Keisuke Ikegami (Aichi Medical University)H-Index: 15
#2Samuel Refetoff (U of C: University of Chicago)H-Index: 103
Last. Takashi Yoshimura (Nagoya University)H-Index: 43
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Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by transcription–translation feedback loops of specific genes, which are referred to as ‘circadian clock genes’. In mammals, the central circadian pacemaker, which is located in the hypothalamic suprachiasmatic nucleus, controls peripheral circadian clocks. The circadian system regulates virtually all physiological processes, which are further modulated by changes in the external environment, such as light exposure and ...
#1Anke Huss (UU: Utrecht University)H-Index: 31
#2Luuk van Wel (UU: Utrecht University)H-Index: 8
Last. Roel Vermeulen (UU: Utrecht University)H-Index: 87
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Background: Exposure to light at night (LAN) can perturb the biological clock and affect sleep and health. Previous epidemiological studies have evaluated LAN levels measured by satellites, but the...
#1Eric L Bolf (UVM: University of Vermont)H-Index: 5
#2Brian L. Sprague (UVM: University of Vermont)H-Index: 43
Last. Frances E. Carr (UVM: University of Vermont)H-Index: 18
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Breast and thyroid cancers are two malignancies with highest incidence in women. These cancers often occur metachronously. Women with thyroid cancer are at increased risk for subsequent breast cancer; women with breast cancer have an increased incidence of later development of thyroid cancer, suggesting a common etiology. This bidirectional relationship is reported worldwide; however, the underlying reasons for this co-occurrence are unknown. In this review, we summarize the current epidemiologi...
#1Young Shin Song (Seoul National University Hospital)H-Index: 13
#2Young Joo Park (SNU: Seoul National University)H-Index: 60
: Since the release of The Cancer Genome Atlas study of papillary thyroid carcinoma (PTC) in 2014, additional genomic studies of differentiated thyroid carcinoma (DTC) using massively-parallel sequencing (MPS) have been published. Recent advances in MPS technology have started to provide important insights into the molecular pathogenesis of DTC. In the genomic landscape, the most recurrently altered genes in DTC, which has a low mutational burden relative to other cancers, are BRAF, RAS, and fus...
#1Javier Menéndez-Menéndez (UC: University of Cantabria)H-Index: 7
#2Carlos Martínez-Campa (UC: University of Cantabria)H-Index: 29
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical trials and multiple experimental studies performed both in vivo and in vitro have documented that the pineal hormone inhibits endocrine-dependent mammary tumors by interfering with ...
#1Miaomiao Sun (CUHK: The Chinese University of Hong Kong)H-Index: 3
#2W. FengH-Index: 1
Last. Lap Ah Tse (CUHK: The Chinese University of Hong Kong)H-Index: 31
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SummaryAims This systematic review and meta-analysis evaluated the associations between shift work patterns and risks of specific types of obesity. Methods PubMed was searched until March 2017 for observational studies that examined the relationships between shift work patterns and obesity. Odds ratio for obesity was extracted using a fixed-effects or random-effects model. Subgroup meta-analyses were carried out for study design, specific obesity types and characteristics of shift work pattern. ...
#1Ruth M. Lunn (NIH: National Institutes of Health)H-Index: 22
#2David E. Blask (Tulane University)H-Index: 43
Last. Windy A. Boyd (NIH: National Institutes of Health)H-Index: 22
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Abstract The invention of electric light has facilitated a society in which people work, sleep, eat, and play at all hours of the 24-hour day. Although electric light clearly has benefited humankind, exposures to electric light, especially light at night (LAN), may disrupt sleep and biological processes controlled by endogenous circadian clocks, potentially resulting in adverse health outcomes. Many of the studies evaluating adverse health effects have been conducted among night- and rotating-sh...
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#2Cari M. KitaharaH-Index: 32
#1Panpan Xiao (CSU: Central South University)
#2Lijun Li (CSU: Central South University)H-Index: 1
Last. Andy S. K. Cheng (PolyU: Hong Kong Polytechnic University)H-Index: 18
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#1Xudan Lou (Fudan University)H-Index: 3
#2Haidong Wang (Fudan University)H-Index: 3
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To study the alterations of sleep quality and circadian rhythm genes expressions upon elderly thyroid nodule patients, the risk factors associated with thyroid malignancies, and the potential relationship involved. The elderly people enrolled in our study were divided into three groups according to the thyroid histopathology: malignant nodule group, benign nodule group, and normal group, and the clinical data and sleep quality were collected. Among the patients of surgery, 56 fresh thyroid tissu...
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