4-Hydroxynonenal is An Oxidative Degradation Product of Polysorbate 80
Abstract
Introduction Polysorbates (PS) are used in biopharmaceuticals to stabilize therapeutic proteins. Oxidative degradation of (poly)unsaturated fatty acids (PUFAs) contained in PS was shown to lead to α,β-unsaturated carbonyls. Aim The n-6-PUFA linoleic acid accounts for up to 18% of all FAs contained in multi-compendial grade PS80. 4-Hydroxynonenal (HNE) is highly reactive towards nucleophilic amino acids, potentially leading to covalent protein...
Paper Details
Title
4-Hydroxynonenal is An Oxidative Degradation Product of Polysorbate 80
Published Date
Feb 1, 2021
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