Internal medicine

Rescue therapy

Portal hypertension

Hepatic encephalopathy

Shunt (medical)

Antibiotics

Gastroenterology

Chemistry

Cirrhosis

Portosystemic shunt

Rifaximin

Transjugular intrahepatic portosystemic shunt

Biochemistry

Medicine

Annals of Internal Medicine

The efficacy of rifaximin in the secondary prevention of overt hepatic encephalopathy (HE) is well documented, but its effectiveness in preventing a first episode in patients after transjugular intrahepatic portosystemic shunt (TIPS) has not been established.To determine whether rifaximin prevents overt HE after TIPS compared with placebo.Randomized, double-blind, multicenter, placebo-controlled trial. (ClinicalTrials.gov: NCT02016196).197 patients with cirrhosis undergoing TIPS for intractable ascites or prevention of variceal rebleeding.Patients were randomly assigned to receive rifaximin (600 mg twice daily) or placebo, beginning 14 days before TIPS and continuing for 168 days after the procedure.The primary efficacy end point was incidence of overt HE within 168 days after the TIPS procedure.An episode of overt HE occurred in 34% (95% CI, 25% to 44%) of patients in the rifaximin group (n = 93) and 53% (CI, 43% to 63%) in the placebo group (n = 93) during the postprocedure period (odds ratio, 0.48 [CI, 0.27 to 0.87]). Neither the incidence of adverse events nor transplant-free survival was significantly different between the 2 groups.The study's conclusion applies mainly to patients with alcoholic cirrhosis, who made up the study population. The potential benefit of rifaximin 6 months after TIPS and beyond remains to be investigated.In patients with cirrhosis treated with TIPS, rifaximin was well tolerated and reduced the risk for overt HE. Rifaximin should therefore be considered for prophylaxis of post-TIPS HE.French Public Health Ministry.

The Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt