Nursing

Psychological intervention

Intensive care medicine

Asthma

Surgery

Chronic rhinosinusitis

Psychiatry

Dermatology

Sinusitis

rhinorrhea

Nose

Paranasal sinuses

Environmental health

Nasal polyps

Disease burden

Chronic disease

Quality of life (healthcare)

Population

Internal medicine

Medicine

Disease

Nasal congestion

Journal of Asthma and Allergy

Abstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammation-mediated disease of the nasal mucosa and paranasal sinuses with an under-recognized clinical, humanistic, and economic burden. Patients with CRSwNP experience a high symptom burden, including nasal congestion, loss of smell, and rhinorrhea, which has a negative impact on physical and mental health-related quality of life, including sleep quality. Existing medical and surgical interventions, including local and systemic corticosteroids and endoscopic sinus surgery, may be associated with recurrence of nasal polyps and associated symptoms and with an increased risk of short- and long-term adverse effects, especially with repeated or long-term use. Because type 2 inflammation is implicated in the pathogenesis of several coexisting diseases, patients with CRSwNP often have comorbid asthma and/or nonsteroidal anti-inflammatory drug-exacerbated respiratory disease. These patients, as well as those with high corticosteroid use and/or sinonasal surgical history, have more severe disease and associated symptom burden and represent a difficult-to-treat population under the existing management paradigm. This article reviews the clinical, humanistic, and economic burden of CRSwNP; it highlights the unmet need for effective and safe CRSwNP therapies that effectively control symptoms and minimize recurrence by targeting the underlying type 2 inflammatory disease pathophysiology. Keywords: disease severity, healthcare economics, paranasal sinus disease, quality of life A Letter to the Editor has been published for this article. A Response to Letter has been published for this article .

Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps