Biology

Pharmacokinetics

Peptide

Oral route

Biochemistry

Bioavailability

Computational biology

Pharmaceutical sciences

Pharmacology

Medicine

Chemistry

Drug Discovery Today

Owing to their structural diversity, peptides are a unique source of innovative active ingredients. However, their development has been challenging because of their disadvantageous pharmacokinetic (PK) properties. Over the past decade, many attempts have been made to improve the oral bioavailability of peptide drugs. In this review, we highlight the most recent and promising techniques aimed at the improvement of the oral bioavailability of peptides. The most recent findings will influence future approaches of pharmaceutical companies in the development of new, more efficient, and safer orally delivered peptides.

New perspectives in oral peptide delivery