Cell biology

Biology

Mesenchymal stem cell

Stem cell

Hallux rigidus

Alternative medicine

Bioinformatics

Internal medicine

Arthrodesis

Medicine

Adipose tissue

Pathology

World Journal of Orthopedics

BACKGROUNDFirst metatarsophalangeal joint arthritis (FMTPA), also known as hallux rigidus, is the most frequent degenerative disease of the foot.Diagnosis is made through both clinical and radiological evaluation.Regenerative medicine showed promising results in the treatment of early osteoarthritis.The aim of the present study was to report the results of a case of FMTPA treated with the injection of autologous adipose-derived mesenchymal stem cells. CASE SUMMARYA gentleman of 50 years of age presented with a painful hallux rigidus grade 2 resistant to any previous conservative treatment (including nonsteroidal antiinflammatory drugs and hyaluronic acid injections).An injection of autologous adipose-derived mesenchymal stem cells into the first metatarsophalangeal joint was performed.No adverse events were reported, and both function and pain scales improved after 9 mo of follow-up. CONCLUSIONThe FMTP joint injection of mesenchymal stem cells improved symptoms and function in our patient with FMTPA at 9 mo of follow-up.

Hallux rigidus treated with adipose-derived mesenchymal stem cells: A case report