Carbene

Catalysis

Functional group

Alkyl

Physical chemistry

Polymer

Combinatorial chemistry

Organic chemistry

Photoredox catalysis

Surface modification

Chemistry

Photocatalysis

European Journal of Organic Chemistry

The amino group is one of the most prevalent functional groups present in a wide range of organic molecules, which has been widely applied in various organic synthesis and pharmaceuticals. Alkyl amines could be converted in a single step into Katritzky salts which could serve as alkyl radical precursors to construct C−C bonds and C−X bonds via C(sp 3 )−N cleavage. This deaminative functionalization could be carried out under transition‐metal catalysis, photocatalysis, carbene catalysis or promoted by base. In this paper, recent developments in the deaminative functionalization of alkyl amines were covered. This review was categorized into four parts according to the nature of the bond formation. Some representative examples and corresponding reaction mechanisms were also summarized.

Recent Developments in Deaminative Functionalization of Alkyl Amines