Physics

Radiology

Pattern recognition (psychology)

Communication noise

Neuroscience

Functional connectivity

Resting state fMRI

Magnetic resonance imaging

Philosophy

Artificial intelligence

Psychology

Functional magnetic resonance imaging

Computer science

Linguistics

Nuclear magnetic resonance

Dynamic functional connectivity

Brain mapping

Neuroimaging

Medicine

Cell Reports

Resting-state functional magnetic resonance imaging (fMRI) is widely used in cognitive and clinical neuroscience, but long-duration scans are currently needed to reliably characterize individual differences in functional connectivity (FC) and brain network topology. In this report, we demonstrate that multi-echo fMRI can improve the reliability of FC-based measurements. In four densely sampled individual humans, just 10 min of multi-echo data yielded better test-retest reliability than 30 min of single-echo data in independent datasets. This effect is pronounced in clinically important brain regions, including the subgenual cingulate, basal ganglia, and cerebellum, and is linked to three biophysical signal mechanisms (thermal noise, regional variability in the rate of T2∗ decay, and S0-dependent artifacts) with spatially distinct influences. Together, these findings establish the potential utility of multi-echo fMRI for rapid precision mapping using experimentally and clinically tractable scan times and will facilitate longitudinal neuroimaging of clinical populations.

Rapid Precision Functional Mapping of Individuals Using Multi-Echo fMRI