Catalysis

Biology

Yield (engineering)

Metallurgy

Materials science

Coupling reaction

Recrystallization (geology)

Molecule

Stereochemistry

Paleontology

Medicinal chemistry

Combinatorial chemistry

Organic chemistry

Oxime

Mannich reaction

Chemistry

Reaction conditions

Organic Letters

Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through a multicomponent reaction under mild conditions is described. Such a transformation was performed under transition-metal-free conditions, affording (E)-oximes in a moderate-to-good yield through recrystallization. Our methodology demonstrates a successful combination of a Mannich-type reaction and radical coupling, providing a green and practical approach for the synthesis of potentially bioactive quinoxalinone-containing molecules.

Synthesis of (<i>E</i>)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions

Synthesis of (E)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions