Internal medicine

Pathology

Organic chemistry

Glycoside

Adverse effect

Integrative medicine

Intensive care medicine

Physical therapy

Chemistry

Traditional Chinese medicine

Alternative medicine

Rheumatoid arthritis

Clinical Practice

Guideline

Tripterygium wilfordii

Tripterygium

Traditional medicine

Medicine

Pharmacology

Medicinal Research Reviews

Tripterygium wilfordii Hook F ( Tw HF)‐based therapy is among the most efficient and crucial therapeutics for the treatment of rheumatoid arthritis (RA), which indicates that Tw HF is a potential source of novel anti‐RA drugs. However, accumulating studies have observed that Tw HF‐based therapy induces multi‐organ toxicity, which prevents the wide use of this herb in clinical practice, although several recent studies have attempted to reduce the toxicity of Tw HF. Notably, our research group developed a “Clinical Practice Guideline for Tripterygium Glycosides/ Tripterygium wilfordii Tablets in the Treatment of Rheumatoid Arthritis” (No. T/CACM 1337‐2020) approved by the China Association of Chinese Medicine to standardize the clinical application of Tw HF‐based therapy and thus avoid adverse effects. Although great strides have been made toward the characterization of Tw HF‐based therapy and revealing its underlying pharmacological and toxicological mechanisms, several crucial gaps in knowledge remain as potential barriers to enhance its therapeutic effects on the premise of safety assurance. This review offers a global view of Tw HF, ranging from its chemical constituents, quality control, clinical observations, and underlying pharmacological mechanisms to toxic manifestations and mechanisms. We focus on the important and emerging aspects of this field and highlight the major challenges and strategies for using novel techniques and approaches to gain new insights into unresolved questions. We hope that this review will improve the understanding of Tw HF application and draw increasing interdisciplinary attention from clinicians that practice both Chinese and Western medicine, basic researchers, and computer scientists.

<i>Tripterygium wilfordii</i>: An inspiring resource for rheumatoid arthritis treatment

Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment