Pathology

Enzyme

Mesenchymal stem cell

Biology

Regenerative medicine

Biomedical engineering

Periodontology

Alkaline phosphatase

Regeneration (biology)

Dental follicle

Dentistry

Deciduous teeth

Oral and maxillofacial surgery

Stem cell

Periodontal ligament stem cells

Periodontal fiber

Tissue engineering

Cell biology

Orthodontics

Genetics

Biochemistry

Medicine

Materials

The reconstruction or repair of oral and maxillofacial functionalities and aesthetics is a priority for patients affected by tooth loss, congenital defects, trauma deformities, or various dental diseases. Therefore, in dental medicine, tissue reconstruction represents a major interest in oral and maxillofacial surgery, periodontics, orthodontics, endodontics, and even daily clinical practice. The current clinical approaches involve a vast array of techniques ranging from the traditional use of tissue grafts to the most innovative regenerative procedures, such as tissue engineering. In recent decades, a wide range of both artificial and natural biomaterials and scaffolds, genes, stem cells isolated from the mouth area (dental follicle, deciduous teeth, periodontal ligament, dental pulp, salivary glands, and adipose tissue), and various growth factors have been tested in tissue engineering approaches in dentistry, with many being proven successful. However, to fully eliminate the problems of traditional bone and tissue reconstruction in dentistry, continuous research is needed. Based on a recent literature review, this paper creates a picture of current innovative strategies applying dental stem cells for tissue regeneration in different dental fields and maxillofacial surgery, and offers detailed information regarding the available scientific data and practical applications.

Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration—A Review