Electrode

Organic chemistry

Combinatorial chemistry

Tandem

Catalysis

Physical chemistry

Composite material

Chemistry

Materials science

Oxindole

Electrochemistry

Advanced Synthesis & Catalysis

The tandem cyclization of acrylamide with diselenides facilitated by electrochemical oxidation was successfully developed. This strategy provided an environmentally friendly method for the construction of C−Se bond. A series of seleno oxindoles with pharmacological activity were obtained by using this well‐designed tandem cyclization strategy. The in vitro antitumor activity of the compounds was also screened through MTT assay. Results showed that the seleno oxindoles exhibited better antitumor activity than other oxindole derivatives. magnified image

Synthesis of Seleno Oxindoles <i>via</i> Electrochemical Cyclization of <i>N</i>‐arylacrylamides with Diorganyl Diselenides

Synthesis of Seleno Oxindoles via Electrochemical Cyclization of N‐arylacrylamides with Diorganyl Diselenides