Pathology

Fetus

Placenta

Infertility

Unexplained infertility

Bioinformatics

Biology

Pathophysiology

Obstetrics

Embryo transfer

Endometritis

Embryo

Immunology

Reproductive medicine

Endometriosis

Endometrium

Decidua

Immunosuppression

Decidualization

Gynecology

Pregnancy

Cell biology

Implantation failure

Genetics

Medicine

Journal of Assisted Reproduction and Genetics

Purpose Chronic endometritis (CE) is a frequent hysteroscopic and histological finding which affects embryo transfer implantation during IVF-ICSI cycles. In particular, CE impairs proper decidualization and, subsequently, implantation. Although this correlation has been clearly clarified, a pathophysiological explanation assembling all the studies performed has not been elucidated yet. For this reason, we have structured a systematic review considering all the original articles that evaluated a pathological element involved in CE and implantation impairment. Methods The authors searched electronic databases and, after screening, collected 15 original articles. These were fully scanned and used to create a summary pathway. Results CE is primarily caused by infections, which lead to a specific cytokine and leukocyte pattern in order to prepare the uterus to fight the noxa. In particular, the immunosuppression requested for a proper semi-allogenic embryo transfer implantation is converted into an immunoreaction, which hampers correct embryo implantation. Moreover, endometrial vascularization is affected and both irregular vessel density and luminal thickening and thrombosis reduce what we have first identified as endometrial flow reserve. Finally, incorrect uterine wave propagation could affect embryo contact with decidua. Conclusion This is the first summary of evidence on CE pathophysiology and its relationship with infertility. Understanding the CE pathophysiology could improve our knowledge in embryo transfer success.

Chronic endometritis and altered embryo implantation: a unified pathophysiological theory from a literature systematic review