Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.

Published on Feb 10, 2021in Journal of Ethnopharmacology3.69
· DOI :10.1016/J.JEP.2020.113453
Yue-Hua Jiang10
Estimated H-index: 10
(SDUTCM: Shandong University of Traditional Chinese Medicine),
Peng Zhang1
Estimated H-index: 1
(SDUTCM: Shandong University of Traditional Chinese Medicine)
+ 4 AuthorsChuan-Hua Yang8
Estimated H-index: 8
(SDUTCM: Shandong University of Traditional Chinese Medicine)
Abstract Ethnopharmacological relevance Banxia Baizhu Tianma decoction (BBTD) is a classical representative prescription for expelling phlegm, extinguishing wind, strengthening the spleen and dissipating excessive fluid in traditional Chinese medicine (TCM). According to both TCM theory and about 300 years of clinical practice, BBTD is especially suitable for hypertensive patients of abdominal obesity and lacking physical activity. Aim of the study The present study tried to interpret the pharmacology of the ancient formula of BBTD. Herein, we focused on the plasma metabonomics of BBTD and evaluated the effect and targets of BBTD on endothelial protective effect. Methods Obesity-related hypertensive mice were induced by high-fat diet for 20 weeks. BBTD (17.8 g/kg) was administered intragastrically for 8 weeks, and telmisartan group (12.5 mg/kg) was used as positive drug. Body weight, blood pressure, triglyceride and cholesterol were recorded to evaluate the efficacy of BBTD in vivo. Lipid deposition in aortic roots was assessed by oil red O staining, while morphology of aortas was observed by HE staining. Ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) was performed to study the plasma non-targeted metabonomics. According to the data of metabonomics, human aortic endothelial cells (HAECs) were treated by oxidized low-density lipoprotein (ox-LDL, 50 μg/mL) with/without BBTD (2, 1 or 0.5 mg/mL). Apoptosis rate (Annexin V-FITC/PI), migration (Transwell), cytoskeleton (Phalloidin) and density of VE-cadherin (Immunofluorescence staining) were used to investigate the effect of BBTD in vitro. Transcriptome sequencing was performed (2 mg/mL BBTD vs ox-LDL) to screen the possible targets of BBTD in endothelial protection against ox-LDL. Results BBTD effectively reduced the body weight and total cholesterol, and decreased 12.1 mmHg in SBP and 10.5 mmHg in DBP of obesity-related hypertensive mice (P  Conclusions BBTD attenuates obesity-related hypertension by regulating metabolism of glycerophospholipids and endothelial protection.
#1Minjoo Kim (Hannam University)H-Index: 2
#2Hye Jin Yoo (Yonsei University)H-Index: 11
Last. Jong Ho Lee (Yonsei University)H-Index: 40
view all 4 authors...
Abstract Background and Aims The increased risk of cardiovascular disease under hypercholesterolemia is due to associations between oxidized low-density lipoprotein (ox-LDL) and lipoprotein-associated phospholipase A2 (Lp-PLA2) and between ox-LDL and coagulant profiles. We investigated the impact of different ox-LDL levels on coagulation time and plasma metabolomes in subjects with borderline hypercholesterolemia. Methods and Results One hundred thirty-one subjects with borderline hypercholester...
2 CitationsSource
#1Yue-Hua Jiang (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 10
#2Xiao Li (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 6
Last. Chuan-Hua Yang (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 8
view all 6 authors...
β-sitosterol is a natural compound widely found in many vegetable oils, nuts and plant medicines which lowers cholesterol levels, production of plasminogen activator, anticancer, antiatherogenic effects. However, it is not well understood about the direct endothelial protection of β-sitosterol against oxidized low-density lipoprotein (ox-LDL). In the present study, β-sitosterol significantly inhibited cell apoptosis (P<0.01), increased cell migration (P<0.01), improved energy metabolism (P<0.05)...
2 CitationsSource
#1Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 84
PURPOSE OF REVIEW: The angiopoietin-like proteins (ANGPTLs), consisting of ANGPTL3, ANGPTL4, and ANGPTL8, have gained significant interest for their role as inhibitors of lipoprotein lipase (LPL) and for their potential as therapeutic targets for correcting dyslipidemia. This review provides an overview of the most relevant new insights on the connection between ANGPTLs, plasma lipids, and coronary artery disease. RECENT FINDINGS: Carriers of loss-of-function variants in ANGPTL3 have a reduced r...
18 CitationsSource
#1Jun Morinaga (Kumamoto University)H-Index: 13
#2Jiabin Zhao (Kumamoto University)H-Index: 7
Last. Yuichi Oike (Kumamoto University)H-Index: 86
view all 13 authors...
Purpose Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 reportedly contribute to progression of metabolic disease, a risk factor for cardiovascular disease (CVD). The purpose of this study was to investigate whether circulating ANGPTL levels are associated with CVD risk after adjustment for potential confounding factors. Methods We conducted a single center, cross-sectional study of 988 Japanese subjects undergoing routine health checks. Serum ANGPTL3, 4, and 8 levels were measured using an enz...
17 CitationsSource
#1Chu Shan Tan (Universiti Sains Malaysia)H-Index: 9
#2Yean Chun Loh (Universiti Sains Malaysia)H-Index: 8
Last. Mun Fei Yam (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 27
view all 7 authors...
Abstract Although Banxia Baizhu Tianma Tang (BBT) has been long administered for hypertensive treatment in Traditional Chinese Medicine (TCM), the ratio of the herbal components that makes up the formulation has not been optimized with respect to the anti-hypertensive effect that it inherently possesses. A newly amended BBT (ABBT) formulation was developed using the evidence-based approach of orthogonal stimulus-response compatibility model. The ABBT showed enhanced therapeutic effect while main...
11 CitationsSource
#1Isola A.M. BrownH-Index: 1
#2Lukas Diederich (HHU: University of Düsseldorf)H-Index: 5
Last. Brant E. Isakson (UVA: University of Virginia)H-Index: 45
view all 9 authors...
Cardiovascular disease is a leading cause of death worldwide and accounts for >17.3 million deaths per year, with an estimated increase in incidence to 23.6 million by 2030.1 Cardiovascular death r...
46 CitationsSource
#1Jahangir Iqbal (SUNY Downstate Medical Center)H-Index: 36
#2Meghan T. Walsh (SUNY Downstate Medical Center)H-Index: 13
Last. M. Mahmood Hussain (SUNY Downstate Medical Center)H-Index: 64
view all 4 authors...
Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and plasma lipoproteins. The cellular and plasma concentrations of sphingolipids are altered in several metabolic disorders and may serve as prognostic and diagnostic markers. Here we discuss various sphingolipid transport mechanisms and highlight how changes in cellular and plasma sphingolipid levels contribute to cardiovascular disease, obesi...
71 CitationsSource
#1Clara Serra-Juhé (ISCIII: Carlos III Health Institute)H-Index: 12
#2Gabriel Á. Martos-Moreno (ISCIII: Carlos III Health Institute)H-Index: 20
Last. Luis A. Pérez-Jurado (ISCIII: Carlos III Health Institute)H-Index: 33
view all 8 authors...
Obesity is a multifactorial disorder with high heritability (50–75%), which is probably higher in early-onset and severe cases. Although rare monogenic forms and several genes and regions of susceptibility, including copy number variants (CNVs), have been described, the genetic causes underlying the disease still remain largely unknown. We searched for rare CNVs (>100kb in size, altering genes and present in 3 standard deviations above the mean at <3 years of age) using SNP array molecular karyo...
19 CitationsSource
#1Bhagirath Chaurasia (Baker IDI Heart and Diabetes Institute)H-Index: 10
#2Vincent A. Kaddai (Baker IDI Heart and Diabetes Institute)H-Index: 5
Last. Scott A. Summers (Baker IDI Heart and Diabetes Institute)H-Index: 49
view all 25 authors...
Summary Adipocytes package incoming fatty acids into triglycerides and other glycerolipids, with only a fraction spilling into a parallel biosynthetic pathway that produces sphingolipids. Herein, we demonstrate that subcutaneous adipose tissue of type 2 diabetics contains considerably more sphingolipids than non-diabetic, BMI-matched counterparts. Whole-body and adipose tissue-specific inhibition/deletion of serine palmitoyltransferase ( Sptlc ), the first enzyme in the sphingolipid biosynthesis...
92 CitationsSource
#1Tzung-Yi Tsai (NCKU: National Cheng Kung University)H-Index: 10
#2Chung-Yi Li (PRC: China Medical University (PRC))H-Index: 52
Last. Chia-Chou Yeh (TCU: Tzu Chi University)H-Index: 17
view all 6 authors...
Abstract Ethnopharmacological relevance Patients with vertigo are reported to exhibit a higher risk of subsequent stroke. However, it remains unclear if Traditional Chinese Medicine (TCM), the most common form of complementary and alternative medicine, can help lower the risk of stroke for these patients. So the aim of the study was to investigate the effects of TCM on stroke risk among patients with vertigo. Materials and methods This longitudinal cohort study used the Taiwanese National Health...
20 CitationsSource
Cited By2
#1Mingzhu Luo (CDUTCM: Chengdu University of Traditional Chinese Medicine)
#2Rong FanH-Index: 1
Last. Chen XueweiH-Index: 2
view all 8 authors...
ETHNOPHARMACOLOGICAL RELEVANCE Gualou Xiebai Banxia decoction (GLXBBX) is a well-known traditional Chinese herbal formula that was first discussed in the Synopsis of the Golden Chamber by Zhang Zhongjing in the Eastern Han Dynasty. In traditional Chinese medicine, GLXBBX is commonly prescribed to treat cardiovascular diseases, such as coronary heart disease and atherosclerosis. OBJECTIVE The present study aimed to examine GLXBBX's preventative capacity and elucidate the potential molecular mecha...
#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
view all 6 authors...
Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling Powder (YCWLP), a famous traditional Chinese medicine prescription, is effective for the treatment of icteric hepatitis, hepatic fibrosis, non-alcoholic fatty liver disease and other liver diseases in clinical practices, however, the underlying mechanisms of YCWLP on HF is still unclear. In this study, 1H NMR and MS-based metabolomics analysis along...
Hypertension is a cardiovascular disease that causes great harm to health and life, affecting the function of important organs and accompanied by a variety of secondary diseases, which need to be treated with drugs for a long time. P. ternata alone or combination with western medicine has played an important role in traditional Chinese medicine. Although P. ternata is used clinically to treat hypertension, its functional molecular mechanism and pharmacological mechanism have not been elucidated....