Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

Volume: 22, Issue: 9, Pages: 1103 - 1115
Published: Aug 24, 2020
Abstract
Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch between collective and single-cell dissemination, controlled by cadherin-mediated cell-cell junctions. In clinical samples, E-cadherin-expressing and -deficient tumours both invade collectively and metastasize equally, implicating additional mechanisms controlling cell-cell cooperation and individualization. Here, using spatially defined organotypic...
Paper Details
Title
Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion
Published Date
Aug 24, 2020
Volume
22
Issue
9
Pages
1103 - 1115
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