Receptor

Peroxisome proliferator-activated receptor

Peroxisome proliferator

Biology

Peroxisome proliferator-activated receptor gamma

Peroxisome

Chemistry

Immunology

Biochemistry

Immune system

Metabolism

Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPARα, PPARγ, and PPARβ/δ. PPARα and PPARδ are highly expressed in oxidative tissues and regulate genes involved in substrate delivery and oxidative phosphorylation (OXPHOS) and regulation of energy homeostasis. In contrast, PPARγ is more important in lipogenesis and lipid synthesis, with highest expression levels in white adipose tissue (WAT).

The role of peroxisome proliferator-activated receptors (PPAR) in immune responses