Gene

Acinetobacter baumannii

Pseudomonas aeruginosa

Cefepime

Bacteria

Biology

Antimicrobial

Agar dilution

Ceftazidime

Cephalosporin

Biochemistry

Antibiotic resistance

Genetics

Minimum inhibitory concentration

Broth microdilution

Antibiotics

Microbiology

Imipenem

Siderophore

Chemistry

Journal of Clinical Microbiology

Cefiderocol (formerly S-649266) is a novel siderophore-conjugated cephalosporin with activity against a broad array of multidrug-resistant (MDR), aerobic Gram-negative bacilli. The siderophore component binds iron and uses active iron transport for drug entry into the bacterial periplasmic space. The cephalosporin moiety is the active antimicrobial component, structurally resembling a hybrid between ceftazidime and cefepime. Like other β-lactam agents, the principal bactericidal activity of cefiderocol occurs via inhibition of bacterial cell wall synthesis by binding of penicillin-binding proteins (PBPs) and inhibiting peptidoglycan synthesis, leading to cell death.

Cefiderocol Antimicrobial Susceptibility Testing Considerations: the Achilles' Heel of the Trojan Horse?