Senolytic drugs: from discovery to translation.
Abstract
Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach. SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases accounting for the bulk of morbidity, mortality and health expenditures. The most deleterious SC are resistant to apoptosis and have up-regulation of...
Paper Details
Title
Senolytic drugs: from discovery to translation.
Published Date
Nov 1, 2020
Journal
Volume
288
Issue
5
Pages
518 - 536
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Notes
History