Context (archaeology)

Type 2 diabetes

Biology

Insulin delivery

Endocrinology

Basal (medicine)

Insulin

Bolus (digestion)

Paleontology

Regimen

Transdermal

Glycemic

Postprandial

Internal medicine

Type 1 diabetes

Pharmacology

Medicine

Diabetes management

Diabetes mellitus

Science Advances

Multiple daily insulin injections have been a common regimen worldwide for the management of diabetes mellitus but involved potential safety and compliance problems. In this context, a single integrated microneedle patch (IMP) with multiple release kinetics is demonstrated to provide better physiologic insulin coverage for postprandial glycemic excursion in a convenient and pain-free manner. The combination of rapid separating technique and multiple individual microneedle arrays provides the combined ability to efficiently deliver insulin into the skin within seconds and to independently control insulin release kinetics. In addition, the diabetic rats with a traditional breakfast-lunch-dinner lifestyle exhibit obvious intraday glucose fluctuations, while the hypoglycemic experiments indicate that the IMP is capable of simultaneous bolus and sustained insulin delivery to closely match the glucose rise that occurs in response to meals and efficiently minimize excessive fluctuations, suggesting the potential of this new transdermal insulin delivery system as substitutes for multiple daily injections.

A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control