Cell biology

Biology

Cytosol

Telecommunications

Biochemistry

Protein folding

Computer science

Endoplasmic reticulum

Unfolded protein response

Endoplasmic-reticulum-associated protein degradation

Degradation (telecommunications)

Enzyme

Chemistry

Biophysics

Protein degradation

Trends in Biochemical Sciences

The endoplasmic reticulum-associated degradation (ERAD) pathway eliminates misfolded proteins. The Hrd1 complex represents the main gate mediating retrotranslocation of ER luminal misfolded (ERAD-L) substrates to the cytosol. A recent cryo-electron microscopy (cryo-EM) study by Wu et al. unveils the structural features of active Hrd1, providing mechanistic insights into the movement of proteins directed for degradation across ER membranes. The endoplasmic reticulum-associated degradation (ERAD) pathway eliminates misfolded proteins. The Hrd1 complex represents the main gate mediating retrotranslocation of ER luminal misfolded (ERAD-L) substrates to the cytosol. A recent cryo-electron microscopy (cryo-EM) study by Wu et al. unveils the structural features of active Hrd1, providing mechanistic insights into the movement of proteins directed for degradation across ER membranes.

ER-associated Protein Degradation at Atomic Resolution