Systemic disease

Herpesviridae

Viral disease

Psychiatry

Dermatology

Drug

Discontinuation

Immunology

Cytomegalovirus

Internal medicine

Pharmacology

Immunopathology

Medicine

Virus

Disease

Eosinophilia

Clinics in Dermatology

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe cutaneous drug reaction characterized by fever, lymphadenopathy, hematologic abnormalities, multisystem involvement, and viral reactivation. Although most patients with DRESS syndrome are able to fully recover, a subset of patients go on to have a prolonged course with recurrence, and/or autoimmune complications. Severe systemic involvement is associated with significant morbidity and mortality. Viral reactivation, especially of human herpes virus 6, Epstein-Barr virus, and cytomegalovirus, is a common feature of DRESS, with a high viral load and antibody titers being associated with poor outcomes. Aside from prompt discontinuation of the offending drug, treatment for patients with significant disease consists of systemic therapy with corticosteroids.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome