Stereocenter

Organic chemistry

Combinatorial chemistry

Reductive elimination

Electrophile

Nickel

Enantioselective synthesis

Coupling (piping)

Catalysis

Chemistry

Metallurgy

Materials science

Alkyl

Coupling reaction

ACS Catalysis

Nickel-catalyzed reductive cross-coupling reactions have emerged as powerful methods to join two electrophiles. These reactions have proven particularly useful for the coupling of sec-alkyl electrophiles to form stereogenic centers; however, the development of enantioselective variants remains challenging. In this Perspective, we summarize the progress that has been made toward Ni-catalyzed enantioselective reductive cross-coupling reactions.

Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions