Gene

Biology

Stromal cell

Long non-coding RNA

Neoadjuvant therapy

Cancer research

Biochemistry

Internal medicine

Chemotherapy

Oncology

Medicine

Breast cancer

Cancer

OncoTargets and Therapy

Abstract: Neoadjuvant chemotherapy (NAC) largely increases operative chances and improves prognosis of the local advanced breast cancer patients. However, no specific means have been invented to predict the therapy responses of patients receiving NAC. Therefore, we focus on the alterations of tumor tissue-related microenvironments such as stromal tumor-infiltrating lymphocytes status, cyclin-dependent kinase expression, non-coding RNA transcription or other small molecular changes, in order to detect potentially predicted biomarkers which reflect the therapeutic efficacy of NAC in different subtypes of breast cancer. Further, possible mechanisms are also discussed to discover feasible treatment targets. Thus, these findings will be helpful to promote the prognosis of breast cancer patients who received NAC and summarized in this review. Keywords: breast cancer, neoadjuvant, chemotherapy, response, predictor

&lt;p&gt;Predictors of Neoadjuvant Chemotherapy Response in Breast Cancer: A Review&lt;/p&gt;

&lt;p&gt;Predictors of Neoadjuvant Chemotherapy Response in Breast Cancer: A Review&lt;/p&gt;

<p>Predictors of Neoadjuvant Chemotherapy Response in Breast Cancer: A Review</p>