Gene

Biology

Autoimmunity

Epigenetics

CpG site

T cell

Immunity

Epigenesis

DNA methylation

Computational biology

Single-nucleotide polymorphism

Immunology

Genetics

Immune system

Genome

Genotype

IL-2 receptor

Treg cell

Human genetics

Gene expression

Most autoimmunity-associated SNPs in the genome map to noncoding regulatory regions in T cells, but the nature of underlying epigenetic mechanisms and any normal purpose in T cell differentiation remain unclear. In this issue of Immunity, Ohkura et al. establish that crucial SNPs linked to autoimmune disease are enriched in DNA regions of CpG demethylation that govern Treg cell development and function.

Genetics Meets Epigenetics in Treg Cells and Autoimmunity