Catalysis

Bioconjugation

Materials science

Receptor

Transition metal

Biochemistry

Inorganic chemistry

Organometallic chemistry

Redox

Thermodynamics

Combinatorial chemistry

Physics

Homogeneous

Ligand (biochemistry)

Nanotechnology

Organic chemistry

Homogeneous catalysis

Computational chemistry

Chemistry

Oxidative addition

Trends in Chemistry

Gold redox chemistry enables selective synthetic methods with a wide range of applications. A number of strategies have been developed to facilitate redox reactions of gold complexes and mechanistic studies have guided their development. The use of gold redox transformations in bioconjugation, materials sciences, and radiochemical synthesis has started to appear. Gold redox chemistry holds the promise of unique reactivities and selectivities that are different to other transition metals. Recent studies have utilized strain release, ligand design, and photochemistry to promote the otherwise sluggish oxidative addition to Au(I) complexes. More details on the reductive elimination from Au(III) complexes have also been revealed. These discoveries have facilitated the development of gold redox catalysis and will continue to offer mechanistic insight and inspiration for other transition metals. This review highlights how research in organometallic chemistry has led to gold redox catalysis, as well as applications in materials science, bioconjugation, and radiochemical synthesis. Gold redox chemistry holds the promise of unique reactivities and selectivities that are different to other transition metals. Recent studies have utilized strain release, ligand design, and photochemistry to promote the otherwise sluggish oxidative addition to Au(I) complexes. More details on the reductive elimination from Au(III) complexes have also been revealed. These discoveries have facilitated the development of gold redox catalysis and will continue to offer mechanistic insight and inspiration for other transition metals. This review highlights how research in organometallic chemistry has led to gold redox catalysis, as well as applications in materials science, bioconjugation, and radiochemical synthesis. a process in which a C–H bond is transformed into a C–Au bond. the reaction that connects two different fragments together. a process in which one ligand of the metal center inserts into another metal–ligand bond. a process in which the metal inserts into a covalent bond and the oxidation state of the metal center increases by two. a form of catalysis that accelerates the reaction via light-promoted redox events. chemical transformations that involve changes in the oxidation states of atoms. an indicator of the tendency of chemical species to gain or lose electrons. a process in which the bonds between the metal center and two X-type ligands break and a covalent bond is formed between two ligands. a measure of relative reaction rates of enantiomers in a kinetic resolution. a process in which an X-type ligand is transferred to the metal center.

Homogeneous Gold Redox Chemistry: Organometallics, Catalysis, and Beyond