Pathology

Stem cell factor

Cytokine

Disease

Fulminant

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Biology

Haematopoiesis

Immunology

Inflammation

Inflammasome

Stem cell

Cytokine storm

Cell biology

Medicine

Leukemia

The scientific community faces an unexpected and urgent challenge related to the SARS-CoV-2 pandemic and is investigating the role of receptors involved in entry of this virus into cells as well as pathomechanisms leading to a cytokine “storm,” which in many cases ends in severe acute respiratory syndrome, fulminant myocarditis and kidney injury. An important question is if it may also damage hematopoietic stem progenitor cells?

SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine “storm” and risk factor for damage of hematopoietic stem cells