Adipose-derived stem cells in wound healing of full-thickness skin defects: a review of the literature.

Published on May 19, 2020in Journal of Plastic Surgery and Hand Surgery1.235
· DOI :10.1080/2000656X.2020.1767116
Maria T Huayllani6
Estimated H-index: 6
(Mayo Clinic),
Rachel Sarabia-Estrada9
Estimated H-index: 9
(Mayo Clinic)
+ 7 AuthorsAntonio J. Forte10
Estimated H-index: 10
(Mayo Clinic)
The complex process of wound healing can be delayed in circumstances when the natural niche is extremely altered. Adipose-derived stem cells (ADSC) seem to be a promising therapy for these type of ...
📖 Papers frequently viewed together
1 Author (Trine Fink)
#1Chen Yang (Fourth Military Medical University)
#1Chen Yang (Fourth Military Medical University)H-Index: 69
Last. Dahai HuH-Index: 26
view all 7 authors...
Abstract Objective Wound healing remains a challenge in burns and trauma fields. Adipose derived stem cells exosomes (AD-exos) had been confirmed to have a positive effect on the wound healing and the migration and proliferation of keratinocyte. However, the mechanism of the AD-exos is still unclear. The objective of this article is to observe the function of the miR-21 expressed in the adipose AD-exos and the effect on migration and proliferation of the HaCaT cells. Materials and methods The fu...
18 CitationsSource
#1Karlien Kallmeyer (University of Pretoria)H-Index: 7
#2Dominik Andre-Levigne (University of Geneva)H-Index: 4
Last. Ali Modarressi (University of Geneva)H-Index: 16
view all 7 authors...
There is increasing interest in the use of adipose-derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and effect of ASCs when administered either systemically or locally during wound repair under physiological conditions. To determine the behavior of ASCs, a rat model with wounds on the dorsal aspect of the hind paws was used and two treatment modes were assessed: ASCs administered sy...
6 CitationsSource
#1Maarten Doornaert (UGent: Ghent University)H-Index: 7
#1Maarten Doornaert (UGent: Ghent University)H-Index: 2
Last. Phillip Blondeel (UGent: Ghent University)H-Index: 48
view all 9 authors...
Abstract Objective Full-thickness cutaneous wounds treated with split-thickness skin grafts often result in unaesthetic and hypertrophic scars. Dermal substitutes are currently used together with skin grafts in a single treatment to reconstruct the dermal layer of the skin, resulting in improved quality of scars. Adipose-derived stem cells (ASCs) have been described to enhance wound healing through structural and humoral mechanisms. In this study, we investigate the compatibility of xenogen-free...
6 CitationsSource
#1Halley Darrach (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 7
#2George Kokosis (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 8
Last. Justin M. Sacks (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 24
view all 6 authors...
BACKGROUND AND OBJECTIVES: Two common options for the closure of complex defects are local flaps and skin grafting. The keystone flap, a fasciocutaneous flap based on perforators, has demonstrated compelling ease of use, reproducibility, and low complication rates without requiring a distant donor site. Our objective for this study was to compare postoperative outcomes for keystone flaps and skin grafts in cancer resection. METHODS: A retrospective review was conducted of patients undergoing key...
3 CitationsSource
#1Tao Ma (GLMU: Guilin Medical University)H-Index: 1
#2Bingchuan Fu (WUST: Wuhan University of Science and Technology)H-Index: 1
Last. Mengxiong Pan (GLMU: Guilin Medical University)H-Index: 1
view all 5 authors...
: Cutaneous wounds, a type of soft tissue injury, are difficult to heal in aging. Differentiation, migration, proliferation, and apoptosis of skin cells are identified as key factors during wound healing processes. Mesenchymal stem cells have been documented as possible candidates for wound healing treatment because their use could augment the regenerative capacity of many tissues. However, the effects of exosomes derived from adipose-derived stem cell (ADSC-exos) on cutaneous wound healing rema...
40 CitationsSource
#1Helena D. Zomer (UFSC: Universidade Federal de Santa Catarina)H-Index: 6
#2Gisele Kristina dos Santos Varela (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
Last. Andréa Gonçalves Trentin (UFSC: Universidade Federal de Santa Catarina)H-Index: 24
view all 6 authors...
: Novel strategies combining cell therapy, tissue engineering, and regenerative medicine have been developed to treat major skin wounds. Although mesenchymal stromal cells (MSCs) from different tissues have similar stem cell features, such as self-renewing mesodermal differentiation potential and expression of immunophenotypic markers, they also have distinct characteristics. Therefore, we aimed to characterize the application of MSCs derived from the dermis and adipose tissue (DSCs and ASCs, re...
8 CitationsSource
#1Meghan E. SambergH-Index: 9
#2Randolph StoneH-Index: 9
Last. Robert J. ChristyH-Index: 29
view all 8 authors...
Abstract Despite great advances in skin wound care utilizing grafting techniques, the resulting severe scarring, deformity and ineffective vascularization remains a challenge. Alternatively, tissue engineering of new skin using patient-derived stem cells and scaffolding materials promises to greatly increase the functional and aesthetic outcome of skin wound healing. This work focused on the optimization of a polyethylene glycol modified (PEGylated) platelet-rich plasma (PRP) hydrogel for the pr...
17 CitationsSource
#1Mohamad Javad Mirzaei-Parsa (Tehran University of Medical Sciences)H-Index: 3
#2Hossein Ghanbari (Tehran University of Medical Sciences)H-Index: 22
Last. Reza Faridi-Majidi (Tehran University of Medical Sciences)H-Index: 19
view all 6 authors...
Full-thickness skin defect is one of the main clinical problems, which cannot be repaired spontaneously. The aim of this study was to evaluate the feasibility of combining nanofibers with ADM as a bilayer scaffold for treatment of full-thickness skin wounds in a single-step procedure. The nanofibrous polycaprolactone/fibrinogen scaffolds were fabricated by electrospinning. Subsequently, mesenchymal stem cells were isolated from rat adipose tissues and characterized by flow cytometry. Cell adhesi...
8 CitationsSource
#1Ling Chuan Hsu (TMU: Taipei Medical University)H-Index: 2
#2Bou-Yue PengH-Index: 1
Last. Keng Liang OuH-Index: 26
view all 8 authors...
: In this study, the wound healing properties of the gelatin-based hydrogel (GBH) wound dressing combined with adipose-derived stem cells (ADSCs) were investigated using the mouse and porcine models. The analytical results showed that the ADSCs harvested from the porcine significantly increased cell growth and promoted cell differentiation (adipogenesis and osteogenesis) in comparison to the ADSCs harvested from the mouse in vitro. Moreover, the in vivo results also indicated that the GBH wound ...
20 CitationsSource
#1Sen Ren (HUST: Huazhong University of Science and Technology)H-Index: 5
#2Jing Chen (HUST: Huazhong University of Science and Technology)H-Index: 4
Last. Zhenbing Chen (HUST: Huazhong University of Science and Technology)H-Index: 8
view all 12 authors...
Human adipose stem cells (ASCs) have emerged as a promising treatment paradigm for skin wounds. Recent works demonstrate that the therapeutic effect of stem cells is partially mediated by extracellular vesicles, which comprise exosomes and microvesicles. In this study, we investigate the regenerative effects of isolated microvesicles from ASCs and evaluate the mechanisms how ASC microvesicles promote wound healing. Adipose stem cell-derived microvesicles (ASC-MVs) were isolated by differential u...
44 CitationsSource
Cited By1
#1Trivia FrazierH-Index: 13
#2Andrea AlarconH-Index: 2
Last. Jeffrey M. GimbleH-Index: 86
view all 15 authors...
Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose-, blood-, and cellulose-de...