A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists
Abstract
l-glutamate is an excitatory neurotransmitter in the central nervous system (CNS), which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel belonging to the iGluRs family. Among NMDA receptor subtypes, GluN2B subtype plays a crucial role in CNS diseases. In this review, we summarize, classify and discuss the reports on GluN2B antagonists, published...
Paper Details
Title
A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists
Published Date
Aug 1, 2020
Volume
200
Pages
112447 - 112447
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