A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway
Abstract
Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make reduced nicotinamide adenine dinucleotide phosphate (NADPH). The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate dehydrogenase (G6PD). Here we develop metabolite reporter and deuterium tracer assays to monitor cellular G6PD activity. Using these, we show that the most...
Paper Details
Title
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway
Published Date
Jan 1, 2020
Journal
Volume
16
Issue
7
Pages
731 - 739
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