Mutualism (biology)

Ecology

Mucosal immunology

Commensalism

Immune system

Intestinal epithelium

Biochemistry

Cytokine

Gut flora

Microbiology

Bacteria

Biology

Host (biology)

Cell biology

Immunity

Interleukin 22

Epithelium

Interleukin

Gastrointestinal tract

Immunology

Genetics

Homeostasis

Annual Review of Immunology

The gastrointestinal tract harbors numerous commensal bacteria, referred to as the microbiota, that benefit host health by digesting dietary components and eliminating pathogens. The intestinal microbiota maintains epithelial barrier integrity and shapes the mucosal immune system, balancing host defense and oral tolerance with microbial metabolites, components, and attachment to host cells. To avoid aberrant immune responses, epithelial cells segregate the intestinal microbiota from immune cells by constructing chemical and physical barriers, leading to the establishment of host-commensal mutualism. Furthermore, intestinal immune cells participate in the maintenance of a healthy microbiota community and reinforce epithelial barrier functions. Perturbations of the microbiota composition are commonly observed in patients with autoimmune diseases and chronic inflammatory disorders. An understanding of the intimate interactions between the intestinal microbiota, epithelial cells, and immune cells that are crucial for the maintenance of intestinal homeostasis might promote advances in diagnostic and therapeutic approaches for various diseases.

Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine