Pathology

Virus

Middle East respiratory syndrome coronavirus

Disease

Endoribonuclease

Severe acute respiratory syndrome coronavirus

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Biology

Gene

RNase P

Virology

Middle East respiratory syndrome

Coronavirus

Computational biology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Genetics

Medicine

Protein Science

Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS‐CoVs and Middle East Respiratory Syndrome coronavirus (MERS‐CoVs), the detailed information about SARS‐CoV‐2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies, and antivirals. We applied high‐throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS‐CoV‐2 proteins and structures. Here we report two high‐resolution crystal structures of endoribonuclease Nsp15/NendoU. We compare these structures with previously reported homologs from SARS and MERS coronaviruses.

Crystal structure of Nsp15 endoribonuclease <scp>NendoU</scp> from <scp>SARS‐CoV</scp>‐2

Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2