Internal medicine

Oxidative stress

Apigenin

Vitexin

Reactive oxygen species

Chemistry

Neuroprotection

Rheumatoid arthritis

Auranofin

Antioxidant

Lipid peroxidation

Flavonoid

Neurotoxicity

Toxicity

Biochemistry

Medicine

Pharmacology

Food Science & Nutrition

Vitexin is an apigenin flavone glycoside found in food and medicinal plants. It has a variety of pharmacological effects, including antioxidant, anti‐inflammatory, anticancer, antinociceptive, and neuroprotective effects. This review study summarizes all the protective effects of vitexin as an antioxidant against reactive oxygen species, lipid peroxidation, and other oxidative damages in a variety of oxidative stress‐related diseases, including seizure, memory impairment, cerebral ischemia, neurotoxicity, myocardial and respiratory injury, and metabolic dysfunction, with possible molecular and cellular mechanisms. This review describes any activation or inhibition of the signaling pathways that depend on the antioxidant activity of vitexin. More basic research is needed on the antioxidative effects of vitexin in vivo, and carrying out clinical trials for the treatment of oxidative stress‐related diseases is also recommended.

Review of the effects of vitexin in oxidative stress‐related diseases