Gene

Biology

Cell nucleus

Genomic organization

Computational biology

Evolutionary biology

Genetics

Chromatin

Genome

Lamin

Transcription factor

Nuclear lamina

Nuclear protein

Human genetics

Genome biology

At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell data. LADs are typically repressive environments in the genome; nonetheless, we discuss findings of lamin interactions with regulatory elements of active genes, and the role lamins may play in genome regulation. We address the relationship between LADs and other genome organizers, and the involvement of LADs in laminopathies. The current data lay the basis for future studies on the significance of lamin-chromatin interactions in health and disease.

Lamina-associated domains: peripheral matters and internal affairs