Programmed cell death

Cell biology

Biology

GPX4

Apoptosis

Biochemistry

Glutathione

Glutathione peroxidase

Immunology

Intracellular

Genetics

Catalase

Necrosis

Immune system

Oxidative stress

Inflammation

Enzyme

Immunogenicity

Tumor necrosis factor alpha

Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been shown to exert anti-inflammatory effects in experimental models of certain diseases. Our review provides an overview of the link between ferroptosis and inflammation; a better understanding of the mechanisms underlying ferroptosis and inflammation may hasten the development of promising therapeutic strategies involving ferroptosis inhibitors to address inflammation.

The emerging role of ferroptosis in inflammation