Gene

Coronavirus

Biology

Virology

Biochemistry

Protein structure

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Drug

Computational biology

Drug discovery

Antiviral drug

Coronavirus disease 2019 (COVID-19)

Protein Data Bank (RCSB PDB)

Bioinformatics

Infectious disease (medical specialty)

Pharmacology

Druggability

Medicine

Chemistry

Virus

Disease

Pathology

Indian Journal of Pharmacology

<br>The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21<sup>th</sup> century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, crystal structure, X-ray crystallography structure, NMR structure, target, and drug target till Feb 3, 2020. The search identified seven major targets (spike protein, envelop protein, membrane protein, protease, nucleocapsid protein, hemagglutinin esterase, and helicase) for which drug design can be considered. There are other 16 nonstructural proteins (NSPs), which can also be considered from the drug design perspective. The major structural proteins and NSPs may serve an important role from drug design perspectives. However, the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs.<br>

Drug for corona virus: A systematic review