Quantum mechanics

Quark

Catalysis

Enantioselective synthesis

Engineering

Axial chirality

Nambu–Jona-Lasinio model

Alkyl

Indole test

Alkene

Stereochemistry

Combinatorial chemistry

Physics

Organic chemistry

Atropisomer

Axial symmetry

Structural engineering

Chirality (physics)

Chemistry

Aryl

Chiral symmetry breaking

Chinese Journal of Chemistry

Summary of main observation and conclusion A new class of axially chiral aryl‐alkene‐indole frameworks have been designed, and the first catalytic asymmetric construction of such scaffolds has been established by the strategy of organocatalytic ( Z / E )‐selective and enantioselective (4+3) cyclization of 3‐alkynyl‐2‐indolylmethanols with 2‐naphthols or phenols (all &gt;95 : 5 E / Z , up to 98% yield, 97% ee). This reaction also represents the first catalytic asymmetric construction of axially chiral alkene‐heteroaryl scaffolds, which will add a new member to the atropisomeric family. This approach has not only confronted the great challenges in constructing axially chiral alkene‐heteroaryl scaffolds but also provided a powerful strategy for the enantioselective construction of axially chiral aryl‐alkene‐indole frameworks.

Axially Chiral <scp>Aryl‐Alkene‐Indole</scp> Framework: A Nascent Member of the Atropisomeric Family and Its Catalytic Asymmetric Construction

Axially Chiral Aryl‐Alkene‐Indole Framework: A Nascent Member of the Atropisomeric Family and Its Catalytic Asymmetric Construction