Sentinel lymph node

Modified Radical Mastectomy

Axillary Lymph Node Dissection

Surgery

Lymph node

Anesthesia

Dissection (medical)

Complication

Seroma

Tranexamic acid

Mastectomy

Blood loss

Internal medicine

Prospective cohort study

Oncology

Medicine

Axillary Dissection

Breast cancer

Cancer

The Breast Journal

The Breast JournalVolume 26, Issue 7 p. 1316-1320 ORIGINAL ARTICLE Role of tranexamic acid in axillary lymph node dissection in breast cancer patients Kush Raj Lohani MBBS, Kush Raj Lohani MBBS orcid.org/0000-0003-2037-8652 Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this authorChitresh Kumar MS, Mch, Chitresh Kumar MS, Mch Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this authorKamal Kataria MS, FACS, FIAGES, Corresponding Author Kamal Kataria MS, FACS, FIAGES drkamalkataria@gmail.com Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, India Correspondence Kamal Kataria, Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Email: drkamalkataria@gmail.comSearch for more papers by this authorAnurag Srivastava MS, FRCS, PhD, MPH, Anurag Srivastava MS, FRCS, PhD, MPH Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this authorPiyush Ranjan MS, Piyush Ranjan MS orcid.org/0000-0002-8975-2449 Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this authorAnita Dhar DNB, PhD, Anita Dhar DNB, PhD Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this author Kush Raj Lohani MBBS, Kush Raj Lohani MBBS orcid.org/0000-0003-2037-8652 Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this authorChitresh Kumar MS, Mch, Chitresh Kumar MS, Mch Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this authorKamal Kataria MS, FACS, FIAGES, Corresponding Author Kamal Kataria MS, FACS, FIAGES drkamalkataria@gmail.com Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, India Correspondence Kamal Kataria, Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Email: drkamalkataria@gmail.comSearch for more papers by this authorAnurag Srivastava MS, FRCS, PhD, MPH, Anurag Srivastava MS, FRCS, PhD, MPH Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this authorPiyush Ranjan MS, Piyush Ranjan MS orcid.org/0000-0002-8975-2449 Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this authorAnita Dhar DNB, PhD, Anita Dhar DNB, PhD Department of Surgical Disciplines, All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaSearch for more papers by this author First published: 15 March 2020 https://doi.org/10.1111/tbj.13810Citations: 6 Kush Raj Lohani and Chitresh Kumar contributed equally in the research work. Presentation: Presented in part at the 2nd annual Asian Society of Mastology (ASOMA) conference, Male, the Maldives (October, 2018). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Axillary lymph node dissection (ALND) is an important step in the management of node-positive operable breast cancer. It is associated with large amount of axillary drainage and increased risk of wound-related infection. Tranexamic acid (TA) has antifibrinolytic property and is being extensively used in controlling blood loss. However, its role in reducing axillary drainage after ALND is still not well-established. The aim of this study is to evaluate the effectiveness of TA in reducing the axillary drainage, early removal of the drain, and decreasing the wound-related infection in breast cancer patients undergoing ALND. This is a prospective nonrandomized double-armed cohort study. Total of 47 patients were included in the TA group and 46 in the nontranexamic (NTA) group. All the patients in TA group received a single dose of intravenous (IV) TA at the time of induction followed by oral TA for five days after surgery. Both TA and NTA groups had similar proportions of locally advanced breast cancers (57.4% vs 56.5%, P = .90). Majority of them underwent modified radical mastectomy (MRM) (70.2% vs 67.4%, P = .76). Patients in TA group had significantly lower axillary drainage (440 ml vs 715.5 ml, P = .003) with earlier removal of the drain (8 vs 11 days, P = .046). Seroma formation (19.1% vs 32.6%, P = .13) and wound-related infection (4.3% vs 8.7%, P = .43) were nonsignificantly lower in the TA group. Tranexamic acid reduces axillary drainage and facilitates early removal of the drain after axillary lymph node dissection. DISCLOSURES None. CONFLICT OF INTEREST Authors have no conflicts of interest. Citing Literature Volume26, Issue7July 2020Pages 1316-1320 RelatedInformation

Role of tranexamic acid in axillary lymph node dissection in breast cancer patients