Catalysis

Enantioselective synthesis

Conjugate

Keto–enol tautomerism

Aldol reaction

Electrophile

Imine

Enol

Polymer

Combinatorial chemistry

Organic chemistry

Mathematics

Copolymer

Acrylate

Mathematical analysis

Addition reaction

Chemistry

Enone

Chemical Reviews

Catalytic reductive coupling of enone, acrylate, or vinyl heteroaromatic pronucleophiles with carbonyl or imine partners offers an alternative to base-mediated enolization in aldol- and Mannich-type reactions. In this review, direct catalytic reductive aldol and Mannich reactions are exhaustively catalogued on the basis of metal or organocatalyst. Stepwise processes involving enone conjugate reduction to form discrete enol or (metallo)enolate derivatives followed by introduction of carbonyl or imine electrophiles and aldol reactions initiated via enone conjugate addition are not covered.

Catalytic Reductive Aldol and Mannich Reactions of Enone, Acrylate, and Vinyl Heteroaromatic Pronucleophiles