New insight into podocyte slit diaphragm, a therapeutic target of proteinuria

Volume: 24, Issue: 3, Pages: 193 - 204
Published: Feb 4, 2020
Abstract
Dysfunction of slit diaphragm, a cell–cell junction of glomerular podocytes, is involved in the development of proteinuria in several glomerular diseases. Slit diaphragm should be a target of a novel therapy for proteinuria. Nephrin, NEPH1, P-cadherin, FAT, and ephrin-B1 were reported to be extracellular components forming a molecular sieve of the slit diaphragm. Several cytoplasmic proteins such as ZO-1, podocin, CD2AP, MAGI proteins and...
Paper Details
Title
New insight into podocyte slit diaphragm, a therapeutic target of proteinuria
Published Date
Feb 4, 2020
Volume
24
Issue
3
Pages
193 - 204
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