Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer’s disease

High salt (sodium) intake leads to the development of hypertension despite the fact that plasma sodium concentration ([Na + ]) is usually normal in hypertensive human patients. Increased cerebrospinal fluid (CSF) sodium contributes to elevated sympathetic activity and high blood pressure (BP) in rodent models of hypertension. However, whether there is an increased accumulation of sodium in the CSF of humans with chronic hypertension is not well...